Diabetes is the most common metabolic disorder out of various lifestyle diseases associated with many complications including
childhood diabetes,
type 1 diabetes,
type 2 diabetes,
diabetes cholestrol, endocrine system diseases, complications of
hypoglycemia, complications of hyperglycemia, advanced type 2 diabetes
treatment, advanced type 1 diabetes treatment, diabetes statistics,
pathophysiology of diabetes, obesity and diabetes,
diabetes and weight loss,
diabetes for dummies, diabetic diet, diabetes and alcohol, reverse
diabetes, latest research on diabetes, diabetes lipid metabolism,
medical diabetes,
diabetes and metabolic syndrome,
etc. The condition develops due to abnormalities in carbohydrate
metabolism and insulin synthesis resulting in high blood sugar with
symptoms such as elevated hunger and thirst, polyuria, glycosuria,
lethargy etc. The journal is focused on cutting edge research in the
prevention, pharmacological treatment, management, and education of
diabetes and related disorders.
Journal of Diabetes & Metabolism is a scholarly Journal publishing articles on all aspects of diabetes including
Type 1 Diabetes Mellitus (insulin-dependent diabetes mellitus) or juvenile diabetes,
Type 2 Diabetes Mellitus
(non-insulin dependent diabetes mellitus), Gestational Diabetes,
Endocrinology, Diabetes Therapy, Diabetic Drugs, Genetics of Diabetes,
obesity with relation to diabetes, risk factors, associated metabolic
disorders etc.
Diabetes Journals are the
peer reviewed
journals and to maintain the quality and standard of the journal
content, reviewer’s agreement and respective editor’s acceptance is must
for publication of an article in this journal. This journal ensures
the barrier-free distribution of its content through online
open access and thus helps in improving the citations for authors and attaining a good
impact factor.
Submit manuscript at
http://editorialmanager.com/acrgroup/ or send as an e-mail attachment to the Editorial Office at
editor.jdm@omicsonline.org
Childhood Diabetes
Childhood diabetes, previously called juvenile diabetes, occurs when the pancreas is unable to produce enough of the hormone
insulin.
Children with the condition will require lifelong insulin injections
and blood sugar monitoring, and a change in diet may be needed.
Type 1 Diabetes
Diabetes mellitus type 1, also known as type 1 diabetes,
formerly insulin-dependent diabetes or juvenile diabetes is a form of
diabetes mellitus that results from the autoimmune destruction of the
insulin-producing beta cells in the pancreas. The subsequent lack of
insulin leads to increased blood and urine
glucose.
Currently there is no way to prevent type 1 diabetes, but ongoing
studies are exploring ways to prevent diabetes in those who are most
likely to develop it.
Type 2 Diabetes
Diabetes mellitus type 2, formerly noninsulin-dependent diabetes mellitus is a metabolic disorder that is characterized by
hyperglycemia (high blood sugar) in the context of
insulin resistance
and relative lack of insulin.In type 2 diabetes, the cells in your
child's body don’t respond to the insulin, and glucose builds up in her
bloodstream. This is called insulin resistance. This could lead to other
conditions in the future, like heart disease, blindness, and kidney
failure.
Diabetes Cholestrol
High cholesterol levels are as serious as high blood
pressure, whether a person is diabetic or non-diabetic. Heart disease
and stroke have both been linked to high
cholesterol and are two of the leading causes of death for diabetics.
Endocrine System Diseases
Endocrine disorders are classified into two categories:
• Endocrine disease that results when a gland produces too much or too little of an
endocrine hormone, called a hormone imbalance.
• Endocrine disease due to the development of lesions (such as nodules
or tumors) in the endocrine system, which may or may not affect hormone
levels
Complications of Hypoglycemia
Over time, repeated episodes of hypoglycemia can lead to
hypoglycemia
unawareness. The body and brain no longer produce signs and symptoms
that warn of a low blood sugar, such as shakiness or irregular
heartbeats. When this happens, the risk of severe, life-threatening
hypoglycemia is increased. Severe low blood sugar is a medical
emergency. It can cause seizures and brain damage. Severe low blood
sugar that causes you to become unconscious is called insulin shock.
Complications of Hyperglycemia
Hyperglycemia,
or high blood sugar (also spelled hyperglycaemia, not to be confused
with the opposite disorder, hypoglycemia) is a condition in which an
excessive amount of glucose circulates in the blood plasma. Temporary
hyperglycemia is often benign and asymptomatic. Blood glucose levels can
rise well above normal for significant periods without producing any
permanent effects or symptoms.
Advances of Diabetes cure
Continuous Glucose Monitoring (CGM) is a relatively new
technology which has the potential to assist people living with type 1
or
type 2 diabetes and treated with insulin to achieve the goal of optimum control of blood glucose.
Advanced Type 2 Diabetes Treatment
Type 2 diabetes,
although less common in very young children, can occur when not enough
insulin is produced or it is not working properly. As a result, glucose
can accumulate in the bloodstream. The condition can often be managed
through a change in diet, increasing exercise and maintaining a healthy
weight, although some patients may require diabetes medication - such as
metformin - or insulin therapy. Type 2 diabetes prevention is possible
by adopting some healthy lifestyle habits and paying attention to
specific preventable diabetes complications associated with this
disease. Maintaining a healthy diet is important for everyone, but it is
especially important for people with diabetes.
Advanced Type 1 Diabetes Treatment
Type 1 diabetes
in children, previously called juvenile diabetes, occurs when the
pancreas is unable to produce enough of the hormone insulin. Children
with the condition will require lifelong insulin injections and blood
sugar monitoring, and a change in diet may be needed. Type 1 diabetes
requires lifelong treatment to keep blood sugar levels within a target
range. Currently there is no way to prevent type 1 diabetes, but ongoing
studies are exploring ways to prevent diabetes in those who are most
likely to develop it.
Diabetes Statistics
In 2012, 29.1 million Americans, or 9.3% of the population,
had diabetes. Approximately 1.25 million American children and adults
have type 1 diabetes.
• Undiagnosed: Of the 29.1 million, 21.0 million were diagnosed, and 8.1 million were undiagnosed.
• Prevalence in Seniors: The percentage of Americans age 65 and older
remains high, at 25.9%, or 11.8 million seniors (diagnosed and
undiagnosed).
• New Cases: The incidence of diabetes in 2012 was 1.7 million new diagnoses/year; in 2010 it was 1.9 million.
• Prediabetes: In 2012, 86 million Americans age 20 and older had
prediabetes; this is up from 79 million in 2010.
• Deaths: Diabetes remains the 7th leading cause of death in the United
States in 2010, with 69,071 death certificates listing it as the
underlying cause of death, and a total of 234,051 death certificates
listing diabetes as an underlying or contributing cause of death.
Pathophysiology of Diabetes
In normal persons the hormone insulin, which is made by the
beta cells of the pancreas, regulates how much glucose is in the blood.
When there is excess of glucose in blood, insulin stimulates cells to
absorb enough glucose from the blood for the energy that they need. In
this condition the immune system attacks and destroys the insulin
producing beta cells of the
pancreas.
There is beta cell deficiency leading to complete insulin deficiency.
Thus is it termed an autoimmune disease where there are anti insulin or
anti-islet cell antibodies present in blood. These cause lymphocytic
infiltration and destruction of the pancreas islets. The destruction may
take time but the onset of the disease is rapid and may occur over a
few days to weeks.
Obesity and Diabetes
Being overweight places extra stress on your body in a
variety of ways, including your body’s ability to maintain proper blood
glucose levels. In fact, being overweight can cause your body to become
resistant to insulin. If you already have diabetes, this means you will
need to take even more insulin to get sugar into your cells. And if you
don’t have diabetes, the prolonged effects of the
insulin resistance
can eventually cause you to develop the disease. Almost 90% of people
living with type 2 diabetes are overweight or have obesity. People who
are overweight or have obesity have added pressure on their body's
ability to use insulin to properly control blood sugar levels, and are
therefore more likely to develop diabetes.
Diabetes and Weight Loss
Cutting back on just one meal can affect the delicate balance of blood sugar,
insulin,
and medication in your body. So it's important to work with an expert
when you diet. Unintentional or unexplained weight loss can be caused by
a number of things, including depression, certain medication and
diabetes. In people with diabetes, insufficient insulin prevents the
body from getting glucose from the blood into the body's cells to use as
energy. When this occurs, the body starts burning fat and muscle for
energy, causing a reduction in overall body weight.
Diabetes for Dummies
Without the pancreas producing this insulin, the sugar will
stay in our blood and begin to create serious health issues. High blood
sugar can cause blindness, kidney failure, nerve damage, and other organ
function problems. And without treating high blood sugar, it can be
fatal. In diabetes for dummy's, it is vital to get tested regularly to
make sure your normal
blood sugar levels
are safe. In the meantime, diabetes for dummy says to check your blood
sugar levels, and know what they are. You only have one body and we all
need to take care of it as best we can.
Diabetic Diet
A diabetes meal plan is a guide that tells you how much and
what kinds of food you can choose to eat at meals and snack times. A
good meal plan should fit in with your schedule and eating habits. Some
meal planning tools include:
• The plate method
• Carb counting
• Glycemic index.
The right meal plan will help you improve your
blood glucose,
blood pressure, and cholesterol numbers and also help keep your weight
on track. Whether you need to lose weight or stay where you are, your
meal plan can help.
Diabetes and Alcohol
If you have diabetes, drinking alcohol will cause your blood
sugar to rise. Plus, alcohol has a lot of calories. If you drink, do it
occasionally and only when your diabetes and blood sugar level are
well-controlled. If you are following a calorie-controlled meal plan,
one drink of alcohol should be counted as two fat exchanges. Here are
some other ways that alcohol can affect diabetes:
• Beer and sweet wine contain carbohydrates and may raise
blood sugar.
• Alcohol stimulates your appetite, which can cause you to overeat and may affect your blood sugar control.
• Alcohol may also affect your judgment or willpower, causing you to make poor food choices.
• Alcohol can interfere with the positive effects of oral diabetes medicines or insulin.
• Alcohol may increase triglyceride levels
Reverse Diabetes
Reversing diabetes is a term used to describe interventions
that reduce dependency on type 2 diabetes medications, effectively
reversing the progression of the illness. With time and dedication,
type 2 diabetes
can be reversed and the results can be very rewarding with less
tiredness and better all round health. Loss of body weight can be
particularly beneficial in helping to reverse the progression of
diabetes. In some cases, people may find they are able to come off
medication, although blood sugar levels should be checked regularly as
reversing progression of diabetes is not a cure.
Latest Research on Diabetes
There is a lot of research on diabetes happening all around the world and the latest include:
March 19, 2015: Research to Identify and Correctly Treat Rare Forms of
Diabetes Some very rare forms of diabetes are caused by single gene
mutations. They are called "monogenic" forms of diabetes and new
research is opening the door to specific treatments for these patients.
November 7, 2014: A Close-Up View of Glucose Transport
Association-funded researcher Dr. Tamir Gonen recently published a
critical study that provides the information needed to design new
diabetes drugs. But it almost didn’t happen.
October 31, 2014: A Genetic Link to
Type 2 Diabetes
in Obesity Although obesity is known to be a significant risk factor
for developing type 2 diabetes, most obese people never develop
diabetes. An Association-funded researcher aims to understand what
factors contribute to diabetes risk in the setting of obesity.
Diabetes Lipid Metabolism
The metabolism of people with diabetes differs to the
metabolism of people without it. In type 2 diabetes, the effectiveness
of insulin is reduced and in
type 1 diabetes,
insulin levels in the body are very low. There is a strong correlation
between BMI and body fat. One of the correlates of insulin resistance is
the blood fatty acid (FA) level. FA levels are strong predictors of
muscle insulin resistance. Muscle fat content is increased in obesity
and more so in type 2 diabetes. Electron microscopy shows decreased
mitochondrial size in muscle from individuals with type 2 diabetes.
Medical Diabetes
Diabetes is a chronic disease in which the body cannot
regulate the amount of sugar in the blood. People with diabetes have
high blood sugar because their body cannot move sugar from the blood
into muscle and fat cells to be burned or stored for energy, and because
their liver makes too much glucose and releases it into the blood. This
is because either:
• Their pancreas does not make enough insulin
• Their cells do not respond to insulin normally
• Both of the above
• Type 2 diabetes may be reversed with lifestyle changes, especially
losing weight with exercise and by eating healthier foods. Some cases of
type 2 diabetes can also be improved with weight-loss surgery.
• There is no cure for
type 1 diabetes.
• Keeping an ideal body weight and an active lifestyle may prevent or delay the start of type 2 diabetes.
• Type 1 diabetes cannot be prevented.
Diabetes and Metabolic Syndrome
The metabolic syndrome is a cluster of the most dangerous
heart attack risk factors: diabetes and prediabetes, abdominal obesity,
high cholesterol and high blood pressure. A quarter of the world’s
adults have metabolic syndrome. People with metabolic syndrome are twice
as likely to die from, and three times as likely to have a heart attack
or stroke compared with people without the syndrome. People with
metabolic syndrome have a five-fold greater risk of developing
type 2 diabetes. Upto 80% of the 200 million people with diabetes globally will die of cardiovascular disease.
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Journal of Diabetes & Metabolism is associated with our international conference "
6th Global Diabetes Summit and Medicare Expo Dubai"
(Diabetes-2015) during November 02-04, 2015, 2015 Dubai, UAE with a
theme “Emerging Interventions & Advancements In Treatment Of
Diabetes”. The major sessions include Clinical Diabetes and Diagnostic
Approaches, Diabetes Management. its complications, Treatment of Type 1
Diabetes, Type 2 Diabetes Genetics of Diabetes, Transplantation for
Diabetes and many other.